There are some problems with an "real" always running Factorio server, the first being that pollution continues to spread, and thus aliens grow / expand and become more violent. I guess you could combat this by setting it up so that aliens only attack when attacked.
For me, mods can make or break the game. I am not into the warped since of "fun" that sea block or bob's mods adds. The bare necessary mods you need (again, my opinion) are Warehouses
& Long reach
, and leave it the rest vanilla. Too many mods causes UPS issues, lag issues, and frankly on a big MP server it's going to frustrate people having to keep all their mods in sync - so the less the better.
I love Factorio - when I play, I PLAY. For that reason, with BFA coming out, I have to stay away from it